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Phenobarbital lowers the plasma levels of dicumarol (name Formerly made use of: bishydroxycoumarin) and results in a minimize in anticoagulant action as measured from the prothrombin time. Barbiturates can induce hepatic microsomal enzymes resulting in elevated metabolism and decreased anticoagulant response of oral anticoagulants (e.Dosages of bar

Barbiturates are metabolized primarily via the hepatic microsomal enzyme program, plus the metabolic solutions are excreted from the urine, and less commonly, within the feces. Around twenty five to 50 p.c of a dose of aprobarbital or phenobarbital is eliminated unchanged in the urine, While the level of other barbiturates excreted unchanged within

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